Melatonin synchronizes the brain and nervous system and biological functions to most of the internal organs including: fetal adrenal gland, pancreas, liver, kidney, heart, lung, fat, gut, etc. Then, various physiological effects of melatonin are reviewed, including detoxification of free radicals and antioxidant actions, bone formation and protection, reproduction, and cardiovascular, immune or body mass regulation. Given these physiological effects, potential benefits of melatonin use is especially useful with regard to brain or gastrointestinal protection, psychiatric disorders, cardiovascular diseases and oncostatic effects. Melatonin has many diverse effects with clinical, preventative and therapeutic applications.
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Curr Neuropharmacol. 2016 Dec 28. Melatonin: pharmacology, functions and therapeutic benefits.